The resurgence of interest in natural therapies has sparked a renaissance in the utilization of non-conventional beverages as emerging biotherapeutics. Sourced from a variety of plants, animals, and minerals, these beverages provide a plethora of bioactive compounds, each with unique physiological impacts. This review explores the scientific foundation underpinning the therapeutic potential of non-conventional beverages, encompassing alcoholic, teas and other miscellaneous beverages. Through an examination of their bioactive compounds, including polyphenols, flavonoids, peptides, vitamins, and minerals, the article elucidates their interactions with biological pathways and cellular processes, highlighting their potential in preventing and managing various health conditions. By consolidating existing knowledge and exploring novel beverages, this review underscores their role as promising agents in the quest for improved human well-being, highlighting their importance in natural therapies and health promotion. This review explores the scientific foundation underpinning the therapeutic potential of non-conventional beverages, encompassing categories such as alcoholic beverages, teas, and other miscellaneous beverages.